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Lines 7 and 190-211: The text focuses on and develops the potential relevance of changes in cellular redox status on Zn homeostasis, suggesting that a condition of oxidative stress could lead to transient increase of intracellular buffered available Zn2+ concentration with impact on signalling and regulation

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Additionally, OCA worsened the circulating lipid profile, as treated patients had increased low-density lipoprotein (LDL) and decreased high-density lipoprotein (HDL) cholesterol levels [83,84,86]

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